Synthesis of Fluorescent 1,7-Dipyridyl-bis-pyrazolo[3,4-b:4',3'-e]pyridines: Design of Reversible Chemosensors for Nanomolar Detection of Cu².

ABSTRACT: An efficient access toward novel tridentate ligands based on 1,7-dipyridinyl-substituted bis-pyrazolo[3,4-b:4',3'-e]pyridines (BPs) and their usefulness as fluorescent probes for cation detection is reported. The synthesis proceeds by a three-step sequence starting from 2-chloropyridine (1), all reactions were performed using microwave radiation under solvent-free conditions, and an overall yield of up to 63% was obtained. Photophysical properties of three representative 1,7-dipyridinyl-BPs (PBPs, 6a-6c) substituted at position 4 with different donor (D) or acceptor (A) groups were investigated. Compounds exhibited large Stokes shift in different solvents and strong blue light emission in both solution and solid state, and quantum yields were as high as 8

SUBMITTER: Garcia M 

PROVIDER: S-EPMC6648379 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature