Amyloid-Based Injectable Hydrogel Derived from Hydrolyzed Hen Egg White Lysozyme.

ABSTRACT: Injectable hydrogels based on synthetic peptides have shown great promise in many biomedical applications. Yet, the high cost generally associated with synthetic peptides hinders the practical use of such peptide-based injectable hydrogel. To overcome this drawback, here, we propose to use the peptides from hydrolyzed low-cost natural protein as an economical and convenient peptide source to prepare an injectable hydrogel. We demonstrate the effectiveness of this alternative strategy using hen egg white lysozyme (HEWL) as an example. We used the peptide fragments from hydrolyzed HEWL as the gelator, and the magnesium ion as the performance enhancer to prepare the injectable hydrogel. We showed that the hydrogel is an amyloid gel as it was formed by a dense network of amyloid fibrils. We al

SUBMITTER: Yang L 

PROVIDER: S-EPMC6648635 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature