Orthogonally "Clickable" Biodegradable Nanofibers: Tailoring Biomaterials for Specific Protein Immobilization.

ABSTRACT: Multifunctionalizable polymeric nanofibers can be tailored for various biomedical applications by selective conjugation of small molecules and bioactive ligands. This study reports the design, synthesis, and application of novel biodegradable polyester-based nanofibers bearing metal-free "clickable" handles. Polylactide-based polymers were synthesized using organo-catalyzed ring-opening polymerization to contain "clickable" chain-end functional groups that specifically react through radical or nucleophilic thiol-ene reactions. A furan-protected maleimide-containing hydroxyl-bearing initiator yielded polymers containing strained oxanorbornene unit at their chain end. In addition, postpolymerization thermal treatment provides maleimide end group-containing polymers. Solution electrospinning

SUBMITTER: Kalaoglu-Altan OI 

PROVIDER: S-EPMC6648765 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature