Thermally Assisted Generation of Protein-Poly(ethylene sodium phosphate) Conjugates with High Mineral Affinity.

ABSTRACT: Protein therapeutics has recently attracted interest in various medical treatments. However, the structure and function preservation in proteins under physiological conditions is still an important issue and reliable immobilization techniques are required. In this study, the thermally assisted complexation of proteins with amphiphilic polyphosphoesters is proposed as a new methodology for their durability improvement. Amphiphilic cholesterol-terminated poly(ethylene sodium phosphate) (CH-PEP·Na) was synthesized via the organocatalytic ring-opening polymerization of 2-methoxy-2-oxo-1,3,2-dioxaphospholane initiated by cholesterol as the hydrophobic molecule and followed by demethylation and neutralization. For the protein nanocarrier preparation, a complex of the amphiphilic CH-PEP·Na with b

SUBMITTER: Noree S 

PROVIDER: S-EPMC6648864 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature