Molecular Modeling-_Based Delivery System Enhances Everolimus-Induced Apoptosis in Caco-2 Cells.

ABSTRACT: Several studies have shown that the mammalian target of rapamycin (mTOR) inhibitor; everolimus (EV) improves patient survival in several types of cancer. However, the meaningful efficacy of EV as a single agent for the treatment of colorectal cancer (CRC) has failed to be proven in multiple clinical trials. Combination therapy is one of the options that could increase the efficacy and decrease the toxicity of the anticancer therapy. This study revealed that the β-cyclodextrin (β-CD):FGF7 complex has the potential to improve the antiproliferative effect of EV by preventing FGF receptor activation and by enhancing EV cellular uptake and intracellular retention. Molecular docking techniques were used to investigate the possible interaction between EV, β-CD, and FGF7. Molecular docking insight

SUBMITTER: Maki MAA 

PROVIDER: S-EPMC6649008 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature