Multiple-Responsive Dendronized Hyperbranched Polymers.

ABSTRACT: By combining topological structures of hyperbranched polymers with dendronized polymers, a series of hyperbranched poly(acylhydrazone)s pendanted with 3-fold branched dendritic oligoethylene glycol (OEG) units were efficiently prepared through A₂ + B₃ polycondensation. The constituents of these dendritic polymers can be mediated through dynamic covalent acylhydrazones. Owing to the dense OEG pendants, these dendronized hyperbranched polymers are biocompatible and thermoresponsive, and their cloud points (T _cps) can be modulated by the branched architecture, solution pH, and addition of a third component. Cell viability in the presence of these hyperbranched poly(acylhydrazone)s can be maintained above 80%. Based on the unique dendritic architecture w

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6649171 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature