Self-Assembly of Diphenylalanine-Peptide Nucleic Acid Conjugates.

ABSTRACT: The synthesis and self-assembled nanostructures of a series of nucleopeptides (NPs) derived from the dipeptide Phe-Phe and the peptide nucleic acid unit which are covalently attached through an amide or a triazole linker are described. Depending on the variables such as protecting groups, linkers, and nucleobases, spherical nanoparticles were observed through scanning electron microscopy and high-resolution transmission electron microscopy images, and the porous nature of representative NPs was corroborated by carboxyfluorescein entrapment. Hydrophobic substituents on different sites of NPs and solvents employed for peptide self-assembly played a crucial role for corresponding morphologies. The stability of nanoparticles was also probed under external stimuli such as pH, temperature, and e

SUBMITTER: Datta D 

PROVIDER: S-EPMC6649282 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature