Liposomal Nanovesicles for Efficient Encapsulation of Staphylococcal Antibiotics.

ABSTRACT: Liposomes are attractive vehicles for localized delivery of antibiotics. There exists, however, a gap in knowledge when it comes to achieving high liposomal loading efficiencies for antibiotics. To address this issue, we investigated three antibiotics of clinical relevance against staphylococcal infections with different hydrophilicity and chemical structure, namely, vancomycin hydrochloride, teicoplanin, and rifampin. We categorized the suitability of different encapsulation techniques on the basis of encapsulation efficiency, lipid requirement (important for avoiding lipid toxicity), and mass yield (percentage of mass retained during the preparation process). The moderately hydrophobic (teicoplanin) and highly hydrophobic (rifampin) antibiotics varied significantly in their encapsulation

SUBMITTER: Gonzalez Gomez A 

PROVIDER: S-EPMC6649299 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature