Insights into Second-Sphere Effects on Redox Potentials, Spectroscopic Properties, and Superoxide Dismutase Activity of Manganese Complexes with Schiff-Base Ligands.

ABSTRACT: Six Mn-Schiff base complexes, [Mn(X-salpn)]^0/+ (salpn = 1,3-bis(sal-ic-ylidenamino)propane, X = H [1], 5-Cl [2], 2,5-F₂ [3], 3,5-Cl₂ [4], 5-NO₂ [5], 3,5-(NO₂)₂ [6]), were synthesized and characterized in solution, and second-sphere effects on their electrochemical and spectroscopic properties were analyzed. The six complexes catalyze the dismutation of superoxide with catalytic rate constants in the range 0.65 to 1.54 × 10⁶ M^-1 s^-1 obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutases assay, in aqueous medium of pH 7.8. In solution, these compounds possess two labile solvent molecules in the axial positions favori

SUBMITTER: Palopoli C 

PROVIDER: S-EPMC6649300 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature