Connectivity-based selection of optimal deep brain stimulation contacts: A feasibility study.

ABSTRACT:

Background

The selection of optimal deep brain stimulation (DBS) parameters is time-consuming, experience-dependent, and best suited when acute effects of stimulation can be observed (e.g., tremor reduction).

Objectives

To test the hypothesis that optimal stimulation location can be estimated based on the cortical connections of DBS contacts.

Methods

We analyzed a cohort of 38 patients with Parkinson's disease (24 training, and 14 test cohort). Using whole-brain probabilistic tractography, we first mapped the cortical regions associated with stimulation-induced efficacy (rigidity, bradykinesia, and tremor improvement) and side effects (paresthesia, motor contractions, and visual disturbances). We then trained a support vector machine classifier to categorize DBS conta

SUBMITTER: Krishna V 

PROVIDER: S-EPMC6649384 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature