Comparison of clinical trial outcome patterns in patients following acute coronary syndromes and in patients with chronic stable atherosclerosis.

ABSTRACT:

Background

The transition of patients with atherosclerotic vascular disease from the acute phase of the disease to the chronic stable atherosclerosis (CSA) phase has not been well characterized. We sought to compare ischemic and bleeding outcomes in hospitalized patients enrolled in clinical trials of non-ST-elevation acute coronary syndrome (ACS) with patients enrolled in outpatient trials of CSA.

Hypothesis

The risk for recurrent events will differ between the 2 populations.

Methods

Patient-level outcome data were evaluated from 3 consecutive trials of patients with ACS with long-term follow-up and 2 trials of patients with CSA. Kaplan-Meier curves were generated for ischemic and bleeding outcomes.

Results

In total, 37 370 patients were included in these anal

SUBMITTER: Mahaffey KW 

PROVIDER: S-EPMC6649385 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature