Dataset Information

Clinical and molecular findings in a cohort of ANO5-related myopathy.

ABSTRACT:

Objective

ANO5-related myopathy is an important cause of limb-girdle muscular dystrophy (LGMD) and hyperCKemia. The main descriptions have emerged from European cohorts, and the burden of the disease worldwide is unclear. We provide a detailed characterization of a large Brazilian cohort of ANO5 patients.

Methods

A national cross-sectional study was conducted to describe clinical, histopathological, radiological, and molecular features of patients carrying recessive variants in ANO5. Correlation of clinical and genetic characteristics with different phenotypes was studied.

Results

Thirty-seven patients from 34 nonrelated families with recessive mutations of ANO5 were identified. The most common phenotype was LGMD, observed in 25 (67.5%) patients, followed by pseudometabolic presentation in 7 (18.9%) patients, isolated asymptomatic hyperCKemia in 4 (10.8%) patients, and distal myopathy in a single patient. Nine patients presented axial involvement, including one patient with isolated axial weakness. The most affected muscles according to MRI were the semimembranosus and gastrocnemius, but paraspinal and abdominal muscles, when studied, were involved in most patients. Fourteen variants in ANO5 were identified, and the c.191dupA was present in 19 (56%) families. Sex, years of disease, and the presence of loss-of-function variants were not associated with specific phenotypes.

Interpretation

We present the largest series of anoctaminopathy outside Europe. The most common European founder mutation c.191dupA was very frequent in our population. Gender, disease duration, and genotype did not determine the phenotype.

SUBMITTER: Silva AMS

PROVIDER: S-EPMC6649425 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

Clinical and molecular findings in a cohort of ANO5-related myopathy.

Silva André M S AMS Coimbra-Neto Antônio R AR Souza Paulo Victor S PVS Winckler Pablo B PB Gonçalves Marcus V M MVM Cavalcanti Eduardo B U EBU Carvalho Alzira A D S AADS Sobreira Cláudia F D R CFDR Camelo Clara G CG Mendonça Rodrigo D H RDH Estephan Eduardo D P EDP Reed Umbertina C UC Machado-Costa Marcela C MC Dourado-Junior Mario E T MET Pereira Vanessa C VC Cruzeiro Marcelo M MM Helito Paulo V P PVP Aivazoglou Laís U LU Camargo Leonardo V D LVD Gomes Hudson H HH Camargo Amaro J S D AJSD Pinto Wladimir B V D R WBVDR Badia Bruno M L BML Libardi Luiz H LH Yanagiura Mario T MT Oliveira Acary S B ASB Nucci Anamarli A Saute Jonas A M JAM França-Junior Marcondes C MC Zanoteli Edmar E

Annals of clinical and translational neurology 20190611 7

<h4>Objective</h4>ANO5-related myopathy is an important cause of limb-girdle muscular dystrophy (LGMD) and hyperCKemia. The main descriptions have emerged from European cohorts, and the burden of the disease worldwide is unclear. We provide a detailed characterization of a large Brazilian cohort of ANO5 patients.<h4>Methods</h4>A national cross-sectional study was conducted to describe clinical, histopathological, radiological, and molecular features of patients carrying recessive variants in AN ...[more]

PMID: 31353849

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Dataset Information

Clinical and molecular findings in a cohort of ANO5-related myopathy.

Objective

Methods

Results

Interpretation

Publications

Clinical and molecular findings in a cohort of ANO5-related myopathy.

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