P75 and neural cell adhesion molecule 1 can identify pathologic Schwann cells in peripheral neuropathies.

ABSTRACT:

Objective

Myelinated Schwann cells (SCs) in adult peripheral nerves dedifferentiate into immature cells in demyelinating neuropathies and Wallerian degeneration. This plastic SC change is actively involved in the myelin destruction and clearance as demyelinating SCs (DSCs). In inherited demyelinating neuropathy, pathologically differentiated and dysmyelinated SCs constitute the main nerve pathology.

Methods

We investigated whether this SC plastic status in human neuropathic nerves could be determined by patient sera to develop disease-relevant serum biomarkers. Based on proteomics analysis of the secreted exosomes from immature SCs, we traced p75 neurotrophin receptor (p75) and neural cell adhesion molecule 1 (NCAM) in the sera of patients with peripheral neuropathy.

Resu

SUBMITTER: Kim YH 

PROVIDER: S-EPMC6649441 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature