Dataset Information

P75 and neural cell adhesion molecule 1 can identify pathologic Schwann cells in peripheral neuropathies.

ABSTRACT:

Objective

Myelinated Schwann cells (SCs) in adult peripheral nerves dedifferentiate into immature cells in demyelinating neuropathies and Wallerian degeneration. This plastic SC change is actively involved in the myelin destruction and clearance as demyelinating SCs (DSCs). In inherited demyelinating neuropathy, pathologically differentiated and dysmyelinated SCs constitute the main nerve pathology.

Methods

We investigated whether this SC plastic status in human neuropathic nerves could be determined by patient sera to develop disease-relevant serum biomarkers. Based on proteomics analysis of the secreted exosomes from immature SCs, we traced p75 neurotrophin receptor (p75) and neural cell adhesion molecule 1 (NCAM) in the sera of patients with peripheral neuropathy.

Results

Enzyme-linked immunosorbent assay (ELISA) revealed that p75 and NCAM were subtype-specifically expressed in the sera of patients with peripheral neuropathy. In conjunction with these ELISA data, pathological analyses of animal models and human specimens suggested that the presence of DSCs in inflammatory neuropathy and of supernumerary nonmyelinating or dysmyelinating SCs in inherited neuropathy could potentially be distinguished by comparing the expression profiles of p75 and NCAM.

Interpretation

This study indicates that the identification of disease-specific pathological SC stages might be a valuable tool for differential diagnosis of peripheral neuropathies.

SUBMITTER: Kim YH

PROVIDER: S-EPMC6649441 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

p75 and neural cell adhesion molecule 1 can identify pathologic Schwann cells in peripheral neuropathies.

Kim Young Hee YH Kim Young Hye YH Shin Yoon Kyung YK Jo Young Rae YR Park Da Kyeong DK Song Min-Young MY Yoon Byeol-A BA Nam Soo Hyun SH Kim Jong Hyun JH Choi Byung-Ok BO Shin Ha Young HY Kim Seung Woo SW Kim Se Hoon SH Hong Young Bin YB Kim Jong Kuk JK Park Hwan Tae HT

Annals of clinical and translational neurology 20190702 7

<h4>Objective</h4>Myelinated Schwann cells (SCs) in adult peripheral nerves dedifferentiate into immature cells in demyelinating neuropathies and Wallerian degeneration. This plastic SC change is actively involved in the myelin destruction and clearance as demyelinating SCs (DSCs). In inherited demyelinating neuropathy, pathologically differentiated and dysmyelinated SCs constitute the main nerve pathology.<h4>Methods</h4>We investigated whether this SC plastic status in human neuropathic nerves ...[more]

PMID: 31353867

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