Key inflammatory pathway activations in the MCI stage of Alzheimer's disease.

ABSTRACT:

Objective

To determine the key inflammatory pathways that are activated in the peripheral and CNS compartments at the mild cognitive impairment (MCI) stage of Alzheimer's disease (AD).

Methods

A cross-sectional study of patients with clinical and biomarker characteristics consistent with MCI-AD in a discovery cohort, with replication in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Inflammatory analytes were measured in the CSF and plasma with the same validated multiplex analyte platform in both cohorts and correlated with AD biomarkers (CSF Aβ42, total tau (t-tau), phosphorylated tau (p-tau) to identify key inflammatory pathway activations. The pathways were additionally validated by evaluating genes related to all analytes in coexpression networks of brai

SUBMITTER: Pillai JA 

PROVIDER: S-EPMC6649519 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature