Platelet inhibitory effect of clopidogrel in patients treated with omeprazole, pantoprazole, and famotidine: a prospective, randomized, crossover study.

ABSTRACT:

Background

Concerns about an inhibitory effect of proton pump inhibitors (PPIs) on clopidogrel metabolism have been raised. Because the pharmacological effect of clopidogrel is dependent on genetically determined activity of the hepatic cytochrome P450 isoenzymes system, it is important to examine the interaction between different PPIs and high on-treatment platelet reactivity (HPR) after controlling for genetic variability. The aim of the study was to assess the effect of 2 PPIs and a histamine-2 (H2) receptor-blocker on platelet reactivity in a crossover trial where each patient was alternately treated with each drug.

Hypothesis

Omeprazole reduces HPR more than other PPI or H2 blockers.

Methods

Patients treated with aspirin and clopidogrel for at least 1 month were

SUBMITTER: Arbel Y 

PROVIDER: S-EPMC6649548 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature