Safety of aspirin desensitization in patients with reported aspirin allergy and cardiovascular disease.

ABSTRACT:

Background

Aspirin (ASA) is the drug of choice in patients with coronary artery disease for primary and secondary prevention. This poses a problem for those patients reporting hypersensitivity to this drug or class of drugs.

Hypothesis

Desensitization to ASA may be carried out safely and effectively in patients with reported ASA or nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity needing ASA for cardiac indications. Our 7-step protocol is one choice for a rapid desensitization protocol.

Methods

A retrospective chart review was conducted evaluating ASA desensitization in patients with reported ASA or NSAID hypersensitivity and a cardiac indication for ASA.

Results

In 160 evaluations over 15 years, 89 desensitizations were performed in both the inpati

SUBMITTER: McMullan KL 

PROVIDER: S-EPMC6649559 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature