Use of high-sensitivity troponin assays predicts mortality in patients with normal conventional troponin assays on admission-insights from a meta-analysis.

ABSTRACT:

Background

Use of high-sensitivity troponin (hs-Tn) assays can detect small levels of myocardial damage previously undetectable with conventional troponin (c-Tn) assays. However, prognostic utility of these hs-Tn assays in prediction of mortality remains unclear in the presence of nonelevated c-Tn levels on admission. A systematic review and meta-analysis was performed to assess mortality risk of patients with hs-Tn elevations in the setting of normal c-Tn levels.

Hypothesis

Patients with hs-Tn elevations with normal c-Tn levels on admission blood samples, drawn to rule out acute coronary syndrome (ACS), have a higher mortality risk than those without hs-Tn or c-Tn elevations.

Methods

A search was made of the PubMed, CENTRAL, EMBASE, CINAHL, EBSCO, and Web of Science

SUBMITTER: Chatterjee S 

PROVIDER: S-EPMC6649604 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature