Virologic Failure Among People Living With HIV Initiating Dolutegravir-Based Versus Other Recommended Regimens in Real-World Clinical Care Settings.

ABSTRACT:

Background

Guidelines for initial antiretroviral treatment (ART) regimens have evolved, with integrase strand transfer inhibitors (INSTIs) increasingly prominent. Research on virologic failure (VF) with INSTI therapy is predominantly from clinical trials not care settings, especially for recently approved medications including dolutegravir. We compared outcomes among people living with HIV (PLWH) who initiated recommended regimens in clinical care across the United States.

Setting

We examined 2 groups of PLWH at 8 clinics who initiated ART regimens (August 1, 2013-March 31, 2017): those ART treatment-naive at initiation, and those treatment-experienced.

Methods

The outcome in this longitudinal cohort study was VF, defined as a viral load of ≥400 copies/mL ≥6 months af

SUBMITTER: Nance RM 

PROVIDER: S-EPMC6649666 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature