The Future Colorectal Cancer Burden Attributable to Modifiable Behaviors: A Pooled Cohort Study.

ABSTRACT:

Background

Previous estimates of the colorectal cancer (CRC) burden attributed to behaviors have not considered joint effects, competing risk, or population subgroup differences.

Methods

We pooled data from seven prospective Australian cohort studies (n = 367 058) and linked them to national registries to identify CRCs and deaths. We estimated the strength of the associations between behaviors and CRC risk using a parametric piecewise constant hazards model, adjusting for age, sex, study, and other behaviors. Exposure prevalence was estimated from contemporary National Health Surveys. We calculated population attributable fractions for CRC preventable by changes to current behaviors, accounting for competing risk of death and risk factor interdependence. Statistical tests we

SUBMITTER: Vajdic CM 

PROVIDER: S-EPMC6649699 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature