Clinical Importance of Myc Family Oncogene Aberrations in Epithelial Ovarian Cancer.

ABSTRACT:

Background

The Myc oncogene family has been implicated in many human malignancies and is often associated with particularly aggressive disease, suggesting Myc as an attractive prognostic marker and therapeutic target. However, for epithelial ovarian cancer (EOC), there is little consensus on the incidence and clinical relevance of Myc aberrations. Here we comprehensively investigated alterations in gene copy number, expression, and activity for Myc and evaluated their clinical significance in EOC.

Methods

To address inconsistencies in the literature regarding the definition of copy number variations, we developed a novel approach using quantitative polymerase chain reaction (qPCR) coupled with a statistical algorithm to estimate objective thresholds for detecting Myc gain/am

SUBMITTER: Jung M 

PROVIDER: S-EPMC6649713 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature