Diverse families of transposable elements affect the transcriptional regulation of stress-response genes in Drosophila melanogaster.

ABSTRACT: Although transposable elements are an important source of regulatory variation, their genome-wide contribution to the transcriptional regulation of stress-response genes has not been studied yet. Stress is a major aspect of natural selection in the wild, leading to changes in the transcriptional regulation of a variety of genes that are often triggered by one or a few transcription factors. In this work, we take advantage of the wealth of information available for Drosophila melanogaster and humans to analyze the role of transposable elements in six stress regulatory networks: immune, hypoxia, oxidative, xenobiotic, heat shock, and heavy metal. We found that transposable elements were enriched for caudal, dorsal, HSF, and tango binding sites in D. melanogaster and for NFE2L2 binding sites

SUBMITTER: Villanueva-Canas JL 

PROVIDER: S-EPMC6649756 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature