Risk of Congenital Malformations in Children Born Before Paternal Cancer.

ABSTRACT:

Background

Increased risk of congenital malformations in children fathered by men treated for cancer might be due to mutagenicity of cancer therapies. Finding of increased malformation prevalence in offspring born before paternal cancer would indicate a treatment-independent mechanism.

Methods

Through national registries, we obtained data on singletons born in Sweden from 1994 to 2014 (n = 1 796 160) and their fathers and mothers (1 092 950/1 092 011). Men with cancer (n = 23 932) fathered 26 601 and 9926 children before and after cancer diagnosis, respectively. Associations between paternal cancer, diagnoses retrieved from the Swedish Cancer Register, and offspring malformations, based on Swedish Medical Birth Register data, were estimated by logistic regression.

Results

SUBMITTER: Al-Jebari Y 

PROVIDER: S-EPMC6649839 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature