Determinants of Mammographic Density Change.

ABSTRACT:

Background

Mammographic density (MD) is a strong risk factor for breast cancer. We examined how breast cancer risk factors are associated with MD area (cm²) change across age.

Methods

We conducted a cohort study of 31 782 Swedish women ages 40-70 years at time of baseline mammogram. Lifestyle and reproductive risk factors were assessed by a web-based questionnaire. MD was measured as dense area using the STRATUS method (mean over the left and right breast). Linear regression analyses with adjustments for age, body mass index (BMI), and menopausal status at baseline were performed to assess the association between breast cancer risk factors and mean baseline MD. To investigate mean MD change across age, linear regression analyses with adjustments for age, BMI, meno

SUBMITTER: Azam S 

PROVIDER: S-EPMC6649843 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature