Efficacy and safety of anakinra for undifferentiated autoinflammatory diseases in children: a retrospective case review.

ABSTRACT:

Objective

The aim was to carry out a retrospective review of the efficacy and safety of anakinra in paediatric patients with undifferentiated autoinflammatory disease (uAID).

Methods

We carried out a retrospective study of children with uAID at a single quaternary centre. The clinical efficacy of anakinra was evaluated using physician global assessment (PGA) and serological response assessed by levels of serum amyloid A and CRP. Safety was assessed by exploring adverse events, including infection and drug reactions.

Results

This study included 22 patients, 64% females and 36% males of median age 7.1 years (range 0.13-14.11 years), with uAID. The median starting dose of anakinra was 2 mg/kg (range 2-6 mg/kg) and the median duration of treatment 19.6 months (range 0.8-1

SUBMITTER: Garg S 

PROVIDER: S-EPMC6649913 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature