Early phase and adaptive design clinical trials in rheumatoid arthritis: a systematic review of early phase trials.

ABSTRACT:

Objective

Adaptive designs can enable highly sophisticated and efficient early phase trials, but the clinical inference from these trials is surrounded by complexity, and currently there is a paucity but steadily increasing amount of use of these designs in all fields of medicine. We aim to review early phase trials in RA to discover those that have used adaptive designs and benchmark trial characteristics.

Methods

From an OVID search for journal articles reporting the results of early phase trials in rheumatology, 35 studies were found, with 9 subsequently excluded; 11 were added from manual searches and 19 from searching the references. Study characteristics were extracted from the 56 papers (describing 62 trials), including the number of arms, number of patients, the prim

SUBMITTER: Pickles T 

PROVIDER: S-EPMC6649924 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature