Enhanced gastrointestinal survivability of recombinant Lactococcus lactis using a double coated mucoadhesive film approach.

ABSTRACT: Vaccine administration via the oral route is preferable to parenteral routes due to ease of administration. To date, most available oral vaccines comprises of live attenuated pathogens as oppose to peptide-based vaccines due to its low bioavailability within the gastrointestinal (GI) tract. Over the years, probiotic-based peptide delivery vehicles comprising of lactic acid bacteria such as Lactococcus lactis has emerged as an interesting alternative due to its generally recognized as safe (GRAS) status, a fully sequenced genome, transient gut colonization time, and is an efficient cellular factory for heterologous protein production. However, its survivability through the GI tract is low, thus better delivery approaches are being explored to improve its bioavailability. In this study, we e

SUBMITTER: Tan EW 

PROVIDER: S-EPMC6650035 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature