AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients.

ABSTRACT:

Introduction

One of the main problems involved in heart transplantation (HT) is antibody-mediated rejection (AMR). Many aspects of AMR are still unresolved, including its etiology, diagnosis and treatment. In this project, we hypothesize that variants in genes involved in B-cell biology in HT patients can yield diagnostic and prognostic information about AMR.

Methods

Genetic variants in 61 genes related to B-cell biology were analyzed by next generation sequencing in 46 HT patients, 23 with and 23 without AMR.

Results

We identified 3 single nucleotide polymorphisms in ITGA4 gene (c.1845G>A, c.2633A>G, and c.2883C>T) that conformed the haplotype AGT-ITGA4. This haplotype is associated with the development of AMR. Moreover, AMR patients with the haplotype AGT-ITGA4 pres

SUBMITTER: Nunez L 

PROVIDER: S-EPMC6650139 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature