Loss of HDAC3 results in nonreceptive endometrium and female infertility.

ABSTRACT: Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus and causes chronic pelvic pain and infertility. However, the exact mechanisms of the pathogenesis of endometriosis-associated infertility are unknown. Epigenetic dysregulation has recently been implicated in infertility. Here, we report a reduction of histone deacetylase 3 (HDAC3) protein amounts in eutopic endometrium of infertile women with endometriosis compared to a control group. To investigate the effect of HDAC3 loss in the uterus, we generated mice with conditional ablation of Hdac3 in progesterone receptor (PGR)-positive cells (Pgr^cre/+Hdac3^f/f ; Hdac3^d/d ). Loss of Hdac3 in the uterus of mice results in infertility

SUBMITTER: Kim TH 

PROVIDER: S-EPMC6650287 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature