A dual-responsive probe for detecting cellular hypoxia using ¹⁹F magnetic resonance and fluorescence.

ABSTRACT: We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

SUBMITTER: Kadakia RT 

PROVIDER: S-EPMC6650319 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature