T-cell exhaustion correlates with improved outcomes in kidney transplant recipients.

ABSTRACT: Continuous antigen stimulation during chronic infection or malignancy can promote functional T cell silencing, a phenomenon called T cell exhaustion. The prevalence and impact of T cell exhaustion following organ transplantation, another immune stimulus with persistently high antigen load, are unknown. Here, we characterized serially collected peripheral blood mononuclear cells from 26 kidney transplant recipients using time-of-flight mass cytometry (CyTOF) to define distinct subsets of circulating exhausted T cells and their relationship to induction therapy and allograft function. We observed an increase in specific subsets of CD4⁺ and CD8⁺ exhausted T cells from pre-transplant to 6-months post-transplant, with greater increases in participants given anti-thymocyte

SUBMITTER: Fribourg M 

PROVIDER: S-EPMC6650324 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature