CD27 Promotes CD4⁺ Effector T Cell Survival in Response to Tissue Self-Antigen.

ABSTRACT: Signaling through CD27 plays a role in T cell activation and memory. However, it is currently unknown how this costimulatory receptor influences CD4⁺ effector T (Teff) cells in inflamed tissues. In the current study, we used a murine model of inducible self-antigen expression in the epidermis to elucidate the functional role of CD27 on autoreactive Teff cells. Expression of CD27 on Ag-specific Teff cells resulted in enhanced skin inflammation when compared with CD27-deficient Teff cells. CD27 signaling promoted the accumulation of IFN-γ and IL-2-producing T cells in skin draining lymph nodes in a cell-intrinsic fashion. Surprisingly, this costimulatory pathway had minimal effect on early T cell activation and proliferation. Instead, signaling through CD27 resulted in the progres

SUBMITTER: Remedios KA 

PROVIDER: S-EPMC6650327 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature