Multi-component heteroarene couplings via polarity-reversed radical cascades.

ABSTRACT: A multi-component radical addition strategy enables difunctionalization of alkenes with heteroarenes and a variety of radical precursors, including N3, P(O)R2, and CF3. This unified approach for coupling diverse classes of electrophilic radicals and heteroarenes to vinyl ethers allows for direct, vicinal C-C as well as C-N, C-P, and C-Rf bond formation.

SUBMITTER: Lear JM 

PROVIDER: S-EPMC6650346 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature