The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations.

ABSTRACT: The lymphatic system contains intraluminal leaflet valves that function to bias lymph flow back towards the heart. These valves are present in the collecting lymphatic vessels, which generally have lymphatic muscle cells and can spontaneously pump fluid. Recent studies have shown that the valves are open at rest, can allow some backflow, and are a source of nitric oxide (NO). To investigate how these valves function as a mechanical valve and source of vasoactive species to optimize throughput, we developed a mathematical model that explicitly includes Ca²⁺ -modulated contractions, NO production and valve structures. The 2D lattice Boltzmann model includes an initial lymphatic vessel and a collecting lymphangion embedded in a porous tissue. The lymphangion segment has mechanicall

SUBMITTER: Li H 

PROVIDER: S-EPMC6650476 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature