Natural compounds from plants controlling leishmanial growth via DNA damage and inhibiting trypanothione reductase and trypanothione synthetase: an in vitro and in silico approach.

ABSTRACT: In the present study, four different natural compounds including quercetin, gallic acid, rutin, and lupeol were studied for their anti-leishmanial potentials with anticipated mechanism of action through in vitro and in silico approaches. Results showed that rutin was exceedingly active (IC₅₀; 91.2 µg/ml) against the promastigote form of Leishmania tropica compared to quercetin (IC₅₀; 182.3 µg/ml), gallic acid (IC₅₀; 198.00 µg/ml) and lupeol (IC₅₀; 200.77 µg/ml). Similarly, rutin was highly active against the amastigote form as well, followed by quercetin, gallic acid and lupeol with IC₅₀ values of 101.3 µg/ml, 137.4 µg/ml, 277.2 µg/ml, and 298.9 µg/ml, respectively. These compounds were found to be nontoxic to human blood erythr

SUBMITTER: Mehwish S 

PROVIDER: S-EPMC6650509 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature