Molecular Systems Biology of Neurodevelopmental Disorders, Rett Syndrome as an Archetype.

ABSTRACT: Neurodevelopmental disorders represent a challenging biological and medical problem due to their genetic and phenotypic complexity. In many cases, we lack the comprehensive understanding of disease mechanisms necessary for targeted therapeutic development. One key component that could improve both mechanistic understanding and clinical trial design is reliable molecular biomarkers. Presently, no objective biological markers exist to evaluate most neurodevelopmental disorders. Here, we discuss how systems biology and "omic" approaches can address the mechanistic and biomarker limitations in these afflictions. We present heuristic principles for testing the potential of systems biology to identify mechanisms and biomarkers of disease in the example of Rett syndrome, a neurodevelopmental diso

SUBMITTER: Faundez V 

PROVIDER: S-EPMC6650571 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature