Multi-species comparisons of snakes identify coordinated signalling networks underlying post-feeding intestinal regeneration.

ABSTRACT: Several snake species that feed infrequently in nature have evolved the ability to massively upregulate intestinal form and function with each meal. While fasting, these snakes downregulate intestinal form and function, and upon feeding restore intestinal structure and function through major increases in cell growth and proliferation, metabolism and upregulation of digestive function. Previous studies have identified changes in gene expression that underlie this regenerative growth of the python intestine, but the unique features that differentiate this extreme regenerative growth from non-regenerative post-feeding responses exhibited by snakes that feed more frequently remain unclear. Here, we leveraged variation in regenerative capacity across three snake species-two distantly related li

SUBMITTER: Perry BW 

PROVIDER: S-EPMC6650723 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature