Distinct clinical and biological implications of CUX1 in myeloid neoplasms.

ABSTRACT: Somatic mutations of the CUT-like homeobox 1 (CUX1) gene (CUX1 ^MT) can be found in myeloid neoplasms (MNs), in particular, in myelodysplastic syndromes (MDSs). The CUX1 locus is also deleted in 3 of 4 MN cases with -7/del(7q). A cohort of 1480 MN patients was used to characterize clinical features and clonal hierarchy associated with CUX1 ^MT and CUX1 deletions (CUX1 ^DEL) and to analyze their functional consequences in vitro. CUX1 ^MT were present in 4% of chronic MNs. CUX1 ^DEL were preferentially found in advanced cases (6%). Most MDS and acute myeloid leukemia (AML) patients with -7/del(7q) and up to 15% of MDS patients and 5% of AML patients diploid for the CUX1 locus exhi

SUBMITTER: Aly M 

PROVIDER: S-EPMC6650742 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature