Hemodynamic Effects on Particle Targeting in the Arterial Bifurcation for Different Magnet Positions.

ABSTRACT: The present study investigated the possibilities and feasibility of drug targeting for an arterial bifurcation lesion to influence the host healing response. A micrometer sized iron particle was used only to model the magnetic carrier in the experimental investigation (not intended for clinical use), to demonstrate the feasibility of the particle targeting at the lesion site and facilitate the new experimental investigations using coated superparamagnetic iron oxide nanoparticles. Magnetic fields were generated by a single permanent external magnet (ferrite magnet). Artery bifurcation exerts severe impacts on drug distribution, both in the main vessel and the branches, practically inducing an uneven drug concentration distribution in the bifurcation lesion area. There are permanently posit

SUBMITTER: Bernad SI 

PROVIDER: S-EPMC6650837 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature