Meta-Analysis of Microarray Expression Studies on Metformin in Cancer Cell Lines.

ABSTRACT: Several studies have demonstrated that metformin (MTF) acts with variable efficiency as an anticancer agent. The pleiotropic anticancer effects of MTF on cancer cells have not been fully explored yet. By interrogating the Gene Expression Omnibus (GEO) for microarray expression data, we identified eight eligible submissions, representing five different studies, that employed various conditions including different cell lines, MTF concentrations, treatment durations, and cellular components. A compilation of the data sets of 13 different conditions contained 443 repeatedly up- and 387 repeatedly down-regulated genes; the majority of these 830 differentially expressed genes (DEGs) were associated with higher MTF concentrations and longer MTF treatment. The most frequently upregulated genes inc

SUBMITTER: Schulten HJ 

PROVIDER: S-EPMC6650866 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature