G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications.

ABSTRACT: Guanine (G)-quadruplexes (G4s) are unique nucleic acid structures that are formed by stacked G-tetrads in G-rich DNA or RNA sequences. G4s have been reported to play significant roles in various cellular events in both macro- and micro-organisms. The identification and characterization of G4s can help to understand their different biological roles and potential applications in diagnosis and therapy. In addition to biophysical and biochemical methods to interrogate G4 formation, G4 fluorescent turn-on ligands can be used to target and visualize G4 formation both in vitro and in cells. Here, we review several representative classes of G4 fluorescent turn-on ligands in terms of their interaction mechanism and application perspectives. Interestingly, G4 structures are commonly identified in DN

SUBMITTER: Umar MI 

PROVIDER: S-EPMC6650947 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature