Conserved G-Quadruplexes Regulate the Immediate Early Promoters of Human Alphaherpesviruses.

ABSTRACT: Human Alphaherpesviruses comprise three members, herpes simplex virus (HSV) 1 and 2 and varicella zoster virus (VZV). These viruses are characterized by a lytic cycle in epithelial cells and latency in the nervous system, with lifelong infections that may periodically reactivate and lead to serious complications, especially in immunocompromised patients. The mechanisms that regulate viral transcription have not been fully elucidated, but the master role of the immediate early (IE) genes has been established. G-quadruplexes are non-canonical nucleic-acid structures that control transcription, replication, and recombination in many organisms including viruses and that represent attractive antiviral targets. In this work, we investigate the presence, conservation, folding and activity

SUBMITTER: Frasson I 

PROVIDER: S-EPMC6651000 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature