Identification of potential drug targets and vaccine candidates in Clostridium botulinum using subtractive genomics approach.

ABSTRACT: A subtractive genomic approach has been utilized for the identification of potential drug targets and vaccine candidates in Clostridium botulinum, the causative agent of flaccid paralysis in humans. The emergence of drug-resistant pathogenic strains has become a significant global public health threat. Treatment with antitoxin can target the neurotoxin at the extracellular level, however, can't converse the paralysis caused by botulism. Therefore, identification of drug targets and vaccine candidates in C. botulinum would be crucial to overcome drug resistance to existing antibiotic therapy. A total of 1729 crucial proteins, including chokepoint, virulence, plasmid and resistance proteins were mined and used for subtractive channel of analysis. This analysis disclosed 15 potential targets,

SUBMITTER: Sudha R 

PROVIDER: S-EPMC6651033 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature