3D-PP: A Tool for Discovering Conserved Three-Dimensional Protein Patterns.

ABSTRACT: Discovering conserved three-dimensional (3D) patterns among protein structures may provide valuable insights into protein classification, functional annotations or the rational design of multi-target drugs. Thus, several computational tools have been developed to discover and compare protein 3D-patterns. However, most of them only consider previously known 3D-patterns such as orthosteric binding sites or structural motifs. This fact makes necessary the development of new methods for the identification of all possible 3D-patterns that exist in protein structures (allosteric sites, enzyme-cofactor interaction motifs, among others). In this work, we present 3D-PP, a new free access web server for the discovery and recognition all similar 3D amino acid patterns among a set of proteins structur

SUBMITTER: Valdes-Jimenez A 

PROVIDER: S-EPMC6651053 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature