Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis.

ABSTRACT:

Objectives

To determine the rate of a first recurrent venous thromboembolism (VTE) event after discontinuation of anticoagulant treatment in patients with a first episode of unprovoked VTE, and the cumulative incidence for recurrent VTE up to 10 years.

Design

Systematic review and meta-analysis.

Data sources

Medline, Embase, and the Cochrane Central Register of Controlled Trials (from inception to 15 March 2019).

Study selection

Randomised controlled trials and prospective cohort studies reporting symptomatic recurrent VTE after discontinuation of anticoagulant treatment in patients with a first unprovoked VTE event who had completed at least three months of treatment.

Data extraction and synthesis

Two investigators independently screened studies, extrac

SUBMITTER: Khan F 

PROVIDER: S-EPMC6651066 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature