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Marylosides A-G, Norcycloartane Glycosides from Leaves of Cymbidium Great Flower 'Marylaurencin'.

ABSTRACT: Seven novel norcycloartane glycosides, maryloside A-G (1-7), were isolated from the leaves of Cymbidium Great Flower 'Marylaurencin', along with a known norcycloartane glycoside, cymbidoside (8). These structures were determined on the basis of mainly NMR experiments as well as chemical degradation and X-ray crystallographic analysis. The isolated compounds (1-6 and 8) were evaluated for the inhibitory activity on lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated nitric oxide (NO) production in RAW 264.7 cells. Consequently, 1 and 3 exhibited moderate activity.

SUBMITTER: Yoneyama T

PROVIDER: S-EPMC6651146 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Marylosides A-G, Norcycloartane Glycosides from Leaves of Cymbidium Great Flower 'Marylaurencin'.

Yoneyama Tatsuro T Iseki Kanako K Noji Masaaki M Imagawa Hiroshi H Hashimoto Toshihiro T Kawano Sachiko S Baba Masaki M Kashiwada Yoshiki Y Yahagi Tadahiro T Matsuzaki Keiichi K Umeyama Akemi A

Molecules (Basel, Switzerland) 20190709 13

Seven novel norcycloartane glycosides, maryloside A-G (1-7), were isolated from the leaves of Cymbidium Great Flower 'Marylaurencin', along with a known norcycloartane glycoside, cymbidoside (8). These structures were determined on the basis of mainly NMR experiments as well as chemical degradation and X-ray crystallographic analysis. The isolated compounds (1-6 and 8) were evaluated for the inhibitory activity on lipopolysaccharide (LPS) and inte ...[more]

PMID: 31323985

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