Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation.

ABSTRACT: Exposure to ionizing radiation induces a complex cascade of systemic and tissue-specific responses that lead to functional impairment over time in the surviving population. However, due to the lack of predictive biomarkers of tissue injury, current methods for the management of survivors of radiation exposure episodes involve monitoring of individuals over time for the development of adverse clinical symptoms and death. Herein, we report on changes in metabolomic and lipidomic profiles in multiple tissues of nonhuman primates (NHPs) that were exposed to a single dose of 7.2 Gy whole-body 60Co γ-radiation that either survived or succumbed to radiation toxicities over a 60-day period. This study involved the delineation of the radiation effects in the liver, kidney, jejunum, heart, lung, and

SUBMITTER: Cheema AK 

PROVIDER: S-EPMC6651211 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature