Dynamics and Mechanisms in the Recruitment and Transference of Histone Chaperone CIA/ASF1.

ABSTRACT: The recruitment and transference of proteins through protein-protein interactions is a general process involved in various biological functions in cells. Despite the importance of this general process, the dynamic mechanism of how proteins are recruited and transferred from one interacting partner to another remains unclear. In this study, we investigated the dynamic mechanisms of recruitment and translocation of histone chaperone CIA/ASF1 for nucleosome disassembly by exploring the conformational space and the free energy profile of unbound DBD(CCG1) and CIA/ASF1-bound DBD(CCG1) systems through extensive molecular dynamics simulations. It was found that there exists three metastable conformational states for DBD(CCG1), an unbound closed state, a CIA/ASF1-bound half-open state, and an open

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6651421 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature