Characterization of the Pathophysiological Role of CD47 in Uveal Melanoma.

ABSTRACT: Uveal melanoma (UM) represents the most frequent primary intraocular tumor, however, limited therapeutic options are still available. We have previously shown that cluster of differentiation 47 (CD47) is significantly upregulated in UM cells following inflammatory stimuli and that it represents a predictor of disease progression. Here, we aimed to better characterize the pathophysiological role of CD47 in UM. We show that CD47 is not modulated at different cancer stages, although patients with the lowest expression of CD47 show significant better progression-free survival, after correcting for the presence of BAP1, GNAQ, and GNA11 mutations. By stratifying patients based on the expression of CD47 in the tumor, we observed that patients with high levels of CD47 have a significant increase i

SUBMITTER: Petralia MC 

PROVIDER: S-EPMC6651482 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature