Alu RNA Modulates the Expression of Cell Cycle Genes in Human Fibroblasts.

ABSTRACT: Alu retroelements, whose retrotransposition requires prior transcription by RNA polymerase III to generate Alu RNAs, represent the most numerous non-coding RNA (ncRNA) gene family in the human genome. Alu transcription is generally kept to extremely low levels by tight epigenetic silencing, but it has been reported to increase under different types of cell perturbation, such as viral infection and cancer. Alu RNAs, being able to act as gene expression modulators, may be directly involved in the mechanisms determining cellular behavior in such perturbed states. To directly address the regulatory potential of Alu RNAs, we generated IMR90 fibroblasts and HeLa cell lines stably overexpressing two slightly different Alu RNAs, and analyzed genome-wide th

SUBMITTER: Cantarella S 

PROVIDER: S-EPMC6651528 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature