The Subgingival Microbiome Relationship to Periodontal Disease in Older Women.

ABSTRACT: Understanding of the oral microbiome in relation to periodontal disease in older adults is limited. The composition and diversity of the subgingival microflora and their oligotypes in health and levels of periodontal disease were investigated in this study on older postmenopausal women. The 16S rRNA gene was sequenced using the Illumina MiSeq platform in 1,206 women aged 53 to 81 y. Presence and severity of periodontal disease were defined by Centers for Disease Control and Prevention/American Academy of Periodontology criteria. Composition of the microbiome was determined by 16S rRNA amplicon sequencing and the abundance of taxa described by the centered log₂-ratio (CLR) transformed operational taxonomic unit (OTU) values. Differences according to periodontal disease status wer

SUBMITTER: Genco RJ 

PROVIDER: S-EPMC6651762 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature